Sodium hyaluronate

Intra-articular
Osteoarthritis of the knee

Intraocular
Surgical aid in the anterior segment during cataract extraction and intraocular lens implantation

Ophthalmic
Dry eye

Topical/Cutaneous
Skin ulcer, Skin wound

May result in precipitation with disinfectants or other agents containing quaternary ammonium salts (e.g. benzalkonium chloride).

Hypersensitivity. Infections or skin diseases in the inj site area (intra-articular).

Patient with glaucoma (intraocular); pre-existing chondrocalcinosis, venous or lymphatic stasis is present in the leg (intra-articular). Joint effusion, if present, must be removed prior to inj (intra-articular). Remove sodium hyaluronate completely from the anterior chamber at the end of surgery (intraocular). Pregnancy and lactation.

Eye disorders: Blurred vision, blepharitis, eyelid itching, eye irritation, conjunctivitis, keratitis superficialis diffusa, corneal oedema, foreign body sensation, redness or burning sensation of the eye.
General disorders and administration site conditions: Inj site pain and inflammation (intra-articular).
Immune system disorders: Hypersensitivity reactions. Rarely, anaphylaxis.
Investigations: Transient increase in IOP (intraocular).
Skin and subcutaneous tissue disorders: Ecchymoses, skin rash.

Intra-articular: Avoid strenuous or prolonged weight-bearing activities for 48 hours after the inj. Topical: Lesions may be covered with a sterile gauze pad or elastic bandage if needed.

Intraocular: Closely monitor IOP, particularly in the early postoperative period.

Description:
Mechanism of Action: Sodium hyaluronate, a high molecular weight fraction of purified natural sodium hyaluronic acid, is widely distributed in the extracellular matrix of connective tissues (particularly in the synovial fluid, umbilical cord, skin, and vitreous and aqueous humour of the eye). It acts as a viscoelastic space filler during ophthalmic surgery and functions as a tissue/joint lubricant to regulate the interactions between adjacent tissues. Topically, it protects the skin against abrasion, friction and desiccation.

Topical cream or gel/ophthalmic solution: Store below 30°C. Intraocular inj: Store between 2-25°C. Do not freeze. Protect from light. Intra-articular inj: Store below 30°C. Do not freeze. Protect from light. Storage recommendations may vary among individual products or between countries (refer to detailed product guidelines).

Emollients, Cleansers & Skin Protectives / Ophthalmic Lubricants / Other Drugs Acting on Musculo-Skeletal System / Other Eye Preparations

M09AX01 - hyaluronic acid ; Belongs to the class of other drugs for disorders of the musculo-skeletal system.
S01KA01 - hyaluronic acid ; Belongs to the class of viscoelastic substances used as ophthalmologic surgical aids.
D03AX05 - hyaluronic acid ; Belongs to the class of other cicatrizants. Used in the treatment of wounds and ulcers.

Anon. Hyaluronate and Derivatives. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 15/02/2024.

Bionect (EPI Health, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 27/10/2023.

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Healon EndoCoat Ophthalmic Viscosurgical Device (Abbott Medical Optics Inc.). U.S. FDA. https://www.fda.gov. Accessed 15/02/2024.

Hialid 0.1 Ophthalmic Solution (Santen Pharma Malaysia Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 27/10/2023.

Hialid 0.1% (Santen Philippines Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 27/10/2023.

Hialid 0.3% (Santen Philippines Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 27/10/2023.

Hyal Prefilled Injection (The Zyfas Medical Co.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 15/02/2024.

Hyalgan (Pharmaforte Singapore Pte Ltd). MIMS Singapore. http://www.mims.com/singapore. Accessed 15/02/2024.

Joint Formulary Committee. Sodium Hyaluronate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 27/10/2023.

Sodium Hyaluronate, Hyaluronic Acid. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 27/10/2023.

TriVisc (OrthogenRx, Inc.). U.S. FDA. https://www.fda.gov. Accessed 15/02/2024.

Vismed Lubricant Eye Drops (TRB Chemedica Hong Kong Ltd). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 15/02/2024.